European markets closed lower on Wednesday as global traders brace themselves for a raft of fresh trade tariffs due to be announced by U.S. President Donald Trump's administration.
After rebounding Tuesday, the regional Stoxx 600 index closed down 0.6%. Most sectors notched declines, though retail and utilities stocks posted slight gains.
The Stoxx 600 healthcare index dropped nearly 2%, as hopes fade for any exemption from duties for the pharmaceutical sector. German pharma and biotech group Bayer was among the worst performers, down almost 4%.
Investors are concerned that the White House could be erring toward more punitive import duties after Trump said earlier this week that his "reciprocal tariffs" plan will target "all countries" when they are announced Wednesday, while the White House said that the tariffs "will be effective immediately." An announcement is due after European markets close on Wednesday.
The Washington Post reported Tuesday that White House aides had drafted a proposal that would levy tariffs of roughly 20% on most imports. The paper, which cited three people familiar with the matter, noted that advisors cautioned that several options were still on the table, however, meaning the 20% tariffs may not materialize. CNBC reached out to the White House for comment and is awaiting a response.
Other trade duties are set to come into effect Wednesday, dubbed "Liberation Day" by the White House, including a 25% levy on "all cars that are not made in the United States."
Asia-Pacific markets were mixed overnight, while U.S. stocks reversed course to trade higher on Wednesday.